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Skelaxin is a muscle relaxant. It works by blocking nerve impulses (or pain sensations) in the brain. Skelaxin is used together with rest and physical therapy to treat discomfort associated with acute skeletal muscle conditions such as pain or injury.
Cost of metaxalone 800 mg /d on weight gain and other outcomes was 0.4 kg on the basis of data from placebo-controlled studies. Safety Data The safety of metaxalone was assessed by postmarketing surveillance. There have been no reports of severe hepatic dysfunction, pancreatitis, or other serious adverse events in clinical trials with this therapy. Nursing Mothers Teratogenicity, Pregnancy, and Lactation Safety and efficacy of metaxalone were assessed in pregnant and lactating women. Teratogenicity studies found neither an increase in fetal growth restriction nor decreased birth weight in mice treated with metaxalone. Metaxalone Online doxycycline tablets has also been administered to generic for metaxalone lactating women with concomitant use of warfarin. No adverse effects were noted, and data from animal studies suggested that oral administration of metaxalone at 0.125 mg/kg to lactating women did not increase their risk of congenital malformations in their offspring or increase breast cancer cases. The safety of metaxalone was assessed in women with breast cancer who consumed >2 g/d of warfarin. After a median follow-up of 22 months, 12% discontinued the drug; 1 case of a mild transient toxic effect resulting from metaxalone (mild nausea, vomiting, and diplopia) occurred in three subjects while they Cefpodoxime proxetil and potassium clavulanate brands were taking metaxalone for the treatment of other cancer. No cases severe toxicity metaxalone generic cost and new of breast cancer occurred in the women receiving warfarin. Nursing Mothers Teratogenicity, Pregnancy, and Lactation In a randomized, double-blind, placebo-controlled trial (n = 1,025), it was determined that metaxalone is not embryotoxic to humans. In rats, oral intake of metaxalone at doses 2.5 mg/kg/day (1-month gestation) or 10 (6-month for 3 months did not cause developmental and reproductive changes. No fetotoxicity cases were seen in rats at doses of 0.5 mg/kg/day or greater. Metaxalone has also been administered to nursing mothers with concomitant metaxalone 800 mg generic use of warfarin. No cases breast cancer occurred in these women; a case of mild transient toxic effect resulting from metaxalone (mild nausea, vomiting, and diplopia) occurred in two subjects while they were taking metaxalone for the treatment of other cancer. Clinical Studies A total of 16 randomized clinical studies (5 of the 7 RCTs) evaluated effect of metaxalone on the development cancer. Results shown in Table 2 are based, part, on the data for animal studies and on placebo. Animal Studies Data shown in Table 2 indicate that metaxalone was well tolerated during the 7 RCTs in which it was administered. Two studies also evaluated the effect of metaxalone on prostate cancer outcomes. One RCT (n = 3,500) demonstrated that metaxalone was not associated with significant decreases in the number of malignant lymph nodes (total, small, and large), a reduced progression-free survival, increased overall and incidence of adverse events compared with placebo. The second RCT (n = 4,800) demonstrated that metaxalone was associated with some increased risk of prostate cancer, but not with a statistically significant increased risk of total and large malignancies (including cancers of the prostate, bladder, and bone). third RCT (n = 3,400) demonstrated that metaxalone administered once daily for 3 years had no effect on the rates of prostate, lung, colorectal, or bladder cancer progression (for total and small malignancies). Only data from the first RCT showed that metaxalone was associated with adverse events occurring in 4.
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